Impact of a computerized distress intolerance intervention on electrocortical reactivity to cannabis and threat cues: A randomized controlled trial.

ABSTRACT:

Objective

Given increasing rates of daily cannabis use and Cannabis Use Disorder (CUD) in the United States, it is imperative to understand CUD mechanisms in high-risk groups. Cannabis users with high distress intolerance (DI) are at elevated risk for severe and chronic CUD, but neural mechanisms linking CUD and DI are unknown. Cross-sectional data suggests that acute stress modulation of the cannabis and threat cue-elicited late positive potential (LPP), a neurophysiological marker of motivated attention, are possible mechanisms. However, longitudinal research is needed to clarify the roles of these elicited LPPs in CUD maintenance.

Method

Sixty cannabis users with high DI were randomized a brief computerized intervention targeting DI or a control intervention. Elicited LPP

SUBMITTER: Macatee RJ 

PROVIDER: S-EPMC9357238 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature