A high-density theta burst paradigm enhances the aftereffects of transcranial magnetic stimulation: Evidence from focal stimulation of rat motor cortex.

ABSTRACT:

Background

Theta burst stimulation (TBS) is an efficient noninvasive neuromodulation paradigm that has been widely adopted, clinically. However, the efficacy of TBS treatment remains similarly modest as conventional 10 Hz repetitive transcranial magnetic stimulation (rTMS).

Objective/hypothesis

To develop a new TBS paradigm that enhances the effects of TMS administration while maintaining high time-efficiency.

Methods

We describe here a new TMS paradigm, named High-Density Theta Burst Stimulation (hdTBS). This paradigm delivers up to 6 pulses per burst, as opposed to only 3 in conventional TBS, while maintaining the inter-burst interval of 200 ms (or 5 Hz) - a critical parameter in inducing long-term potentiation. This paradigm was implemented on a TMS stimulator deve

SUBMITTER: Meng Q 

PROVIDER: S-EPMC9357274 | biostudies-literature | 2022 May-Jun

REPOSITORIES: biostudies-literature