RNA exosome drives early B cell development via noncoding RNA processing mechanisms.

ABSTRACT: B cell development is linked to successful V(D)J recombination, allowing B cell receptor expression and ultimately antibody secretion for adaptive immunity. Germline noncoding RNAs (ncRNAs) are produced at immunoglobulin (Ig) loci during V(D)J recombination, but their function and posttranscriptional regulation are incompletely understood. Patients with trichohepatoenteric syndrome, characterized by RNA exosome pathway component mutations, exhibit lymphopenia, thus demonstrating the importance of ncRNA surveillance in B cell development in humans. To understand the role of RNA exosome in early B cell development in greater detail, we generated mouse models harboring a B cell-specific cre allele (Mb1^cre), coupled to conditional inversion-deletion alleles of one RNA

SUBMITTER: Laffleur B 

PROVIDER: S-EPMC9357289 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature