Accuracy of high-risk HPV DNA PCR, p16^(INK4a) immunohistochemistry or the combination of both to diagnose HPV-driven oropharyngeal cancer.

ABSTRACT:

Background

The incidence of high-risk human papillomavirus (hrHPV)-driven head and neck squamous cell carcinoma, in particular oropharyngeal cancers (OPC), is increasing in high-resource countries. Patients with HPV-induced cancer respond better to treatment and consequently have lower case-fatality rates than patients with HPV-unrelated OPC. These considerations highlight the importance of reliable and accurate markers to diagnose truly HPV-induced OPC.

Methods

The accuracy of three possible test strategies, i.e. (a) hrHPV DNA PCR (DNA), (b) p16^(INK4a) immunohistochemistry (IHC) (p16), and (c) the combination of both tests (considering joint DNA and p16 positivity as positivity criterion), was analysed in tissue samples from 99 Belgian OPC patients enrolled in th

SUBMITTER: Simoens C 

PROVIDER: S-EPMC9357318 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature