ELIMINATOR: essentiality analysis using multisystem networks and integer programming.

ABSTRACT: A gene is considered as essential when it is indispensable for cells to grow and replicate in a certain environment. However, gene essentiality is not a structural property but rather a contextual one, which depends on the specific biological conditions affecting the cell. This circumstantial essentiality of genes is what brings the attention of scientist since we can identify genes essential for cancer cells but not essential for healthy cells. This same contextuality makes their identification extremely challenging. Huge experimental efforts such as Project Achilles where the essentiality of thousands of genes is measured together with a plethora of molecular data (transcriptomics, copy number, mutations, etc.) in over one thousand cell lines can shed light on the causality behind the es

SUBMITTER: Antoranz A 

PROVIDER: S-EPMC9357337 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature