HMGB1-activatied NLRP3 inflammasome induces thrombocytopenia in heatstroke rat.

ABSTRACT:

Background

Thrombocytopenia, an early common complication in heatstroke (HS), has been widely considered as a mortality predictor of HS. The mechanism underlying thrombocytopenia in HS remains unknown. It is not known whether NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is activated in HS platelet, which, in turn, induces platelet activation and thrombocytopenia. This study tried to clarify the activation of the NOD-like receptor signaling pathway under HS conditions and investigate its roles in mediating HS-induced thrombocytopenia.

Methods

Rat HS models were established in a certain ambient temperature and humidity. Platelets, isolated from blood, were counted and CD62P, an index of platelet activation, was measured by flow cytometry in all rats.

SUBMITTER: Yin H 

PROVIDER: S-EPMC9357367 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature