Somatic genomic changes in single Alzheimer's disease neurons.

ABSTRACT: Dementia in Alzheimer's disease progresses alongside neurodegeneration^1-4, but the specific events that cause neuronal dysfunction and death remain poorly understood. During normal ageing, neurons progressively accumulate somatic mutations⁵ at rates similar to those of dividing cells^6,7 which suggests that genetic factors, environmental exposures or disease states might influence this accumulation⁵. Here we analysed single-cell whole-genome sequencing data from 319 neurons from the prefrontal cortex and hippocampus of individuals with Alzheimer's disease and neurotypical control individuals. We found that somatic DNA alterations increase in individuals with Alzheimer's disease, with distinct molecular patterns. Normal neurons accumulate mutations

SUBMITTER: Miller MB 

PROVIDER: S-EPMC9357465 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature