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PTP1B Inhibition Improves Mitochondrial Dynamics to Alleviate Calcific Aortic Valve Disease Via Regulating OPA1 Homeostasis.

ABSTRACT: There are currently no pharmacological therapies for calcific aortic valve disease (CAVD). Here, we evaluated the role of protein tyrosine phosphatase 1B (PTP1B) inhibition in CAVD. Up-regulation of PTP1B was critically involved in calcified human aortic valve, and PTP1B inhibition had beneficial effects in preventing fibrocalcific response in valvular interstitial cells and LDLR^-/- mice. In addition, we reported a novel function of PTP1B in regulating mitochondrial homeostasis by interacting with the OPA1 isoform transition in valvular interstitial cell osteogenesis. Thus, these findings have identified PTP1B as a potential target for preventing aortic valve calcification in patients with CAVD.

SUBMITTER: Liu F

PROVIDER: S-EPMC9357565 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature

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PTP1B Inhibition Improves Mitochondrial Dynamics to Alleviate Calcific Aortic Valve Disease Via Regulating OPA1 Homeostasis.

Liu Feng F Chen Jinyong J Hu Wangxing W Gao Chenyang C Zeng Zhiru Z Cheng Si S Yu Kaixiang K Qian Yi Y Xu Dilin D Zhu Gangjie G Zhao Jing J Liu Xianbao X Wang Jian'an J

JACC. Basic to translational science 20220725 7

There are currently no pharmacological therapies for calcific aortic valve disease (CAVD). Here, we evaluated the role of protein tyrosine phosphatase 1B (PTP1B) inhibition in CAVD. Up-regulation of PTP1B was critically involved in calcified human aortic valve, and PTP1B inhibition had beneficial effects in preventing fibrocalcific response in valvular interstitial cells and LDLR<sup>-/-</sup> mice. In addition, we reported a novel function of PTP1B in regulating mitochondrial homeostasis by int ...[more]

PMID: 35958694

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