Identifying RBBP7 as a Promising Diagnostic Biomarker for BK Virus-Associated Nephropathy.

ABSTRACT: BK virus-associated nephropathy (BKVN) remains a major infectious complication due to powerful immunosuppression in kidney transplant recipients, and its histologic appearance can mimic rejection, leading to diagnostic and treatment dilemmas thus molecular diagnostic methods would be beneficial. We collected gene expression profiles of 169 kidney biopsies taken from BKVN, rejection, and stable functioning allografts, based on single sample gene set enrichment analysis and random forest algorithm, and three hallmark activities associated with DNA damage and proliferation were found to be relatively specific in BKVN. Subsequently, weighted gene co-expression network analysis and support vector machines (SVM) algorithm identified RBBP7 as a robust and promising biomarker with high accu

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9357817 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature