Reduced leukocyte mitochondrial copy number in metabolic syndrome and metabolically healthy obesity.

ABSTRACT:

Objective

This study aimed to investigate the associations between peripheral blood leukocyte mitochondrial copy number, metabolic syndrome, and adiposity-related body composition phenotypes in a high prevalence population.

Methods

A single center cross-sectional study was conducted, consisting of 521 middle-aged subjects of Maltese-Caucasian ethnicity. Participants were stratified according to the presence of metabolic syndrome and different metabolic health definitions based on NCEP-ATP III criteria. Relative leukocyte mitochondrial DNA copy number was determined by quantitative polymerase chain reaction and corrected for leukocyte and platelet count. The associations between mitochondrial copy number and metabolic syndrome components was evaluated and adjusted for age and

SUBMITTER: Agius R 

PROVIDER: S-EPMC9357898 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature