Dataset Information

Impact of MMP2 rs243849 and rs14070 genetic polymorphisms on the ischemic stroke susceptibility in Chinese Shaanxi population.

ABSTRACT:

Background

Ischemic stroke (IS) is a complex neurological disease affected by genetics and environment. Matrix metalloproteinase-2 (MMP2) is involved in extracellular matrix (ECM) degradation, inflammation and angiogenesis to regulate the development and recovery of IS.

Purposes

The aim of this study was to explore the association of rs1053605, rs243849 and rs14070 in MMP2 with the risk of IS in Chinese Shaanxi population.

Methods

In this study, 677 IS patients and 681 normal controls were recruited. Rs1053605, rs243849 and rs14070 in MMP2 were genotyped. Logistic regression analysis was applied to evaluate the association of rs1053605, rs243849 and rs14070 in MMP2 with IS susceptibility and the association of environmental factors with MMP2 genetic susceptibility to IS.

Results

The results of the overall analysis demonstrated that rs14070 in MMP2 significantly reduced the risk of IS in Chinese Shaanxi population (OR = 0.767, 95% CI = 0.619-0.952, P = 0.016). Subgroup analysis illustrated that rs243849 in MMP2 evidently increased the risk of IS among drinkers, while rs14070 in MMP2 apparently reduced IS susceptibility among females, participants with aged >55, smokers and drinkers.

Conclusions

Collectively, rs243849 and rs14070 in MMP2 were significantly associated with the risk of IS in Chinese Shaanxi population, and the effect of MMP2 to IS may be associated with its genetic susceptibility.

SUBMITTER: Li S

PROVIDER: S-EPMC9358222 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Impact of <i>MMP2</i> rs243849 and rs14070 genetic polymorphisms on the ischemic stroke susceptibility in Chinese Shaanxi population.

Li Shilin S Yang Shiyao S Zhang Xiaobo X Zhang Yu Y Zhang Jie J Zhang Xiao X Li Weiping W Niu Xiaochen X Shi Wenzhen W Zhang Gejuan G Chang Mingze M Tian Ye Y

Frontiers in neurology 20220725

<h4>Background</h4>Ischemic stroke (IS) is a complex neurological disease affected by genetics and environment. Matrix metalloproteinase-2 (<i>MMP2</i>) is involved in extracellular matrix (ECM) degradation, inflammation and angiogenesis to regulate the development and recovery of IS.<h4>Purposes</h4>The aim of this study was to explore the association of rs1053605, rs243849 and rs14070 in <i>MMP2</i> with the risk of IS in Chinese Shaanxi population.<h4>Methods</h4>In this study, 677 IS patient ...[more]

PMID: 35959401

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