Transient and Steady-State Properties of Drosophila Sensory Neurons Coding Noxious Cold Temperature.

ABSTRACT: Coding noxious cold signals, such as the magnitude and rate of temperature change, play essential roles in the survival of organisms. We combined electrophysiological and computational neuroscience methods to investigate the neural dynamics of Drosophila larva cold-sensing Class III (CIII) neurons. In response to a fast temperature change (-2 to -6°C/s) from room temperature to noxious cold, the CIII neurons exhibited a pronounced peak of a spiking rate with subsequent relaxation to a steady-state spiking. The magnitude of the peak was higher for a higher rate of temperature decrease, while slow temperature decrease (-0.1°C/s) evoked no distinct peak of the spiking rate. The rate of the steady-state spiking depended on the magnitude of the final temperature and was higher at lower t

SUBMITTER: Maksymchuk N 

PROVIDER: S-EPMC9358291 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature