Diffusion Kurtosis Imaging maps neural damage in the EAE model of multiple sclerosis.

ABSTRACT: Diffusion kurtosis imaging (DKI) is an imaging modality that yields novel disease biomarkers and in combination with nervous tissue modeling, provides access to microstructural parameters. Recently, DKI and subsequent estimation of microstructural model parameters has been used for assessment of tissue changes in neurodegenerative diseases and associated animal models. In this study, mouse spinal cords from the experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis (MS) were investigated for the first time using DKI in combination with biophysical modeling to study the relationship between microstructural metrics and degree of animal dysfunction. Thirteen spinal cords were extracted from animals with varied grades of disability and scanned in a high-field MRI scanner a

SUBMITTER: Chuhutin A 

PROVIDER: S-EPMC9358435 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature