Gut microbiota diversity in middle-aged and elderly patients with end-stage diabetic kidney disease.

ABSTRACT:

Background

Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease (ESRD), but the mechanism between DKD and ESRD remains unclear. Some experts have put forward the "microbial-centered ESRD development theory", believing that the bacterial load caused by gut microecological imbalance and uremia toxin transfer are the core pathogenic links. The purpose of this study was to analyze the genomic characteristics of gut microbiota in patients with ESRD, specifically DKD or non-diabetic kidney disease (NDKD).

Methods

In this cross-sectional study, patients with ESRD were recruited in a community, including 22 DKD patients and 22 NDKD patients matched using gender and age. Fecal samples of patients were collected for 16S rDNA sequencing and gut microbiota a

SUBMITTER: Chen R 

PROVIDER: S-EPMC9358493 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature