Salvianolic acid B alleviates neurological injury by upregulating stanniocalcin 1 expression.

ABSTRACT:

Background

Salvianolic acid B (Sal B) is a representative component of phenolic acids derived from the dried root and rhizome of Salvia miltiorrhiza Bge. (Labiatae), which promotes angiogenesis in myocardial infarction and diabetic cardiomyopathy. However, whether Sal B has a neuroprotective function in ischemic stroke by promoting angiogenesis is still unclear.

Methods

In the present study, ischemic stroke models were induced in rats by middle cerebral artery occlusion (MCAO), and Sal B (10 or 20 mg/kg/d) was intraperitoneally injected according to a previous study. Neurological deficits were evaluated by the modified Longa five-point scale, modified Bederson scores and cerebral infarction sizes by triphenyltetrazolium chloride (TTC) staining. Apoptotic cells were te

SUBMITTER: Bi SJ 

PROVIDER: S-EPMC9358494 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature