Drug discovery in spinal cord injury-induced osteoporosis: a text mining-based study.

ABSTRACT:

Background

Spinal cord injury (SCI) and osteoporosis (OP) are common diseases in spine surgery, and OP could be the complication of SCI. However, SCI-induced OP is a complex pathologic process and drug discovery is limited, which restricts the study in the mechanism and treatment of the disease. This study aims to identify the genes and molecular pathways related to SCI-induced OP through computational tools and public datasets, and to explore drug targeting therapy, ultimately preventing the occurrence of OP after SCI.

Methods

In this study, common genes related to SCI and OP were obtained by text mining, then which conducted the functional analysis. Protein-protein interaction (PPI) networks were constructed by STRING online and Cytoscape software. Finally, core genes and

SUBMITTER: Wang C 

PROVIDER: S-EPMC9358497 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature