Functional roles of epitranscriptomic marks in the cardiovascular system and disease: a narrative review.

ABSTRACT:

Background and objective

The recent emergence of epitranscriptomics provides an avenue for identifying RNA modifications implicated in the pathophysiology of human disease. To date, over 170 RNA modifications have been identified; these modifications are important because they can affect the fate of RNAs, including their decay, maturation, splicing, stability, and translational efficiency. Although RNA modifications have been reported in many tissues and disease contexts, detailed functional studies in the heart and cardiovascular disease are only beginning to be reported.

Methods

The search for relevant articles related to epitranscriptomics was conducted by focusing on the cardiovascular system and disease in the PubMed database.

Key content and findings

We summariz

SUBMITTER: Ilieva M 

PROVIDER: S-EPMC9358509 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature