Association of PCSK9 levels and genetic polymorphisms with stroke recurrence and functional outcome after acute ischemic stroke.

ABSTRACT:

Background

Protein convertase subtilisin/kexin type 9 (PCSK9) is a hepatic protein that participated in the lipid homeostasis. Its high levels and polymorphisms are associated with high low-density lipoprotein cholesterol, increasing the vascular risk potentially. However, the association between PCSK9 levels, genetic polymorphisms, and ischemic stroke remains unclear. We aimed to study the relationship between PCSK9 levels, genetic polymorphisms, and stroke outcomes in patients with ischemic stroke.

Methods

A total of 9,782 acute ischemic stroke patients registered in the China National Stroke Registry-III were included in this prospective study. Circulating PCSK9 concentrations and 11 key single-nucleotide polymorphisms (SNPs) were examined. The clinical outcomes included

SUBMITTER: Chen W 

PROVIDER: S-EPMC9358512 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature