Dual anti-platelet therapy for secondary prevention in intracranial atherosclerotic disease: a network meta-analysis.

ABSTRACT:

Background

Intracranial arterial stenosis (ICAS) is a non-marginal cause of stroke/transient ischemic attacks (TIAs) and is associated with high stroke recurrence rate. Some studies have investigated the best secondary prevention ranging from antithrombotic therapy to endovascular treatment (ET). However, no direct comparison between all the possible treatments is currently available especially between single and dual anti-platelet therapies (SAPT and DAPT).

Aim

To establish whether DAPT is more effective than SAPT in preventing the recurrence of ICAS-related stroke, by means of a network meta-analysis (NMA).

Design

Systematic review and NMA in accordance to PRISMA guidelines.

Data sources and methods

We performed a systematic review of trials investigating sec

SUBMITTER: Reale G 

PROVIDER: S-EPMC9358568 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature