Radionuclide ¹³¹I-labeled albumin-indocyanine green nanoparticles for synergistic combined radio-photothermal therapy of anaplastic thyroid cancer.

ABSTRACT:

Objectives

Anaplastic thyroid cancer (ATC) cells cannot retain the radionuclide iodine 131 (¹³¹I) for treatment due to the inability to uptake iodine. This study investigated the feasibility of combining radionuclides with photothermal agents in the diagnosis and treatment of ATC.

Methods

¹³¹I was labeled on human serum albumin (HSA) by the standard chloramine T method. ¹³¹I-HSA and indocyanine green (ICG) were non-covalently bound by a simple stirring to obtain ¹³¹I-HSA-ICG nanoparticles. Characterizations were performed in vitro. The cytotoxicity and imaging ability were investigated by cell/in vivo experiments. The radio-photothermal therapy efficacy of the nanoparticles was evaluated at the cellular and in vivo

SUBMITTER: Zhang X 

PROVIDER: S-EPMC9358776 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature