The Use of Bruton Tyrosine Kinase Inhibitors in Waldenstrom's Macroglobulinemia.

ABSTRACT: The use of Bruton Tyrosine Kinase (BTK) inhibitors in Waldenström's Macroglobulinemia (WM) is evolving. Ibrutinib, a first-generation BTK inhibitor, is currently approved for use in frontline and relapsed/refractory disease. Second-generation BTK inhibitors are being used and studied to improve clinical outcomes and/or safety profile. Zanubrutinib, one such second-generation inhibitor, was recently approved in treatment-naive and refractory/relapsed patients. Here, we review the use of BTK inhibitors in WM in front-line and refractory or relapsed settings. We also highlight common adverse events, the emergence of BTK inhibitors resistance, and future directions of their use.

SUBMITTER: Ababneh O 

PROVIDER: S-EPMC9358782 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature