Transcriptome analysis of immune cells from Behcet's syndrome patients: the importance of IL-17-producing cells and antigen-presenting cells in the pathogenesis of Behcet's syndrome.

ABSTRACT:

Background

Behçet's syndrome (BS) is an immune-mediated disease characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin symptoms. HLA-B51, as well as other genetic polymorphisms, has been reported to be associated with BS; however, the pathogenesis of BS and its relationship to genetic risk factors still remain unclear. To address these points, we performed immunophenotyping and transcriptome analysis of immune cells from BS patients and healthy donors.

Methods

ImmuNexUT is a comprehensive database consisting of RNA sequencing data and eQTL database of immune cell subsets from patients with immune-mediated diseases and healthy donors, and flow cytometry data and transcriptome data from 23 BS patients and 28 healthy donors from the ImmuNexUT study were utili

SUBMITTER: Okubo M 

PROVIDER: S-EPMC9358821 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature