Neutrophil trogocytosis during their trans-endothelial migration: role of extracellular CIRP.

ABSTRACT:

Background

Neutrophils are the most abundant innate immune cells in the circulating blood, and they act as the first responder against bacterial and fungal infection. However, accumulation of activated neutrophils can cause severe inflammation and tissue damage. Recently, neutrophil trogocytosis or membrane transfer with neighboring cells was reported to modulate immune responses. Extracellular cold-inducible RNA binding protein (eCIRP) is a newly identified damage-associated molecular pattern (DAMP). eCIRP can activate neutrophils to be more pro-inflammatory. This study aimed to identify the role of eCIRP in neutrophil trogocytosis during their trans-endothelial migration.

Methods

A trans-endothelial migration (TEM) assay using bone marrow neutrophils and mouse primary lung

SUBMITTER: Takizawa S 

PROVIDER: S-EPMC9358840 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature