Evaluation of cerium oxide as a phosphate binder using 5/6 nephrectomy model rat.

ABSTRACT:

Background

The number of chronic kidney disease (CKD) patients continues to increase worldwide. CKD patients need to take phosphate binders to manage serum phosphorus concentrations. Currently, several types of phosphate binder, including lanthanum carbonate, are used. However, they each have disadvantages.

Methods

In this study, we evaluated cerium oxide as a new phosphate binder in vitro and in vivo. First, cerium oxide was mixed with phosphoric acid at pH 2.5 or 7.0, and residual phosphoric acid was measured by absorption photometry using colorimetric reagent. Second, cerium oxide was fed to 5/6 nephrectomy model rats (5/6Nx), a well-known renal damage model. All rats were measured food intake, water intake, feces volume, and urine volume, and collected serum and urine we

SUBMITTER: Hashimoto A 

PROVIDER: S-EPMC9358871 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature