Neuronal-enriched extracellular vesicles in individuals with IBS: A pilot study of COMT and BDNF.

ABSTRACT:

Background

Irritable bowel syndrome (IBS) is characterized by abdominal pain, bowel habit alterations, and psychiatric comorbidities. Although pathophysiology remains incompletely understood, prior work demonstrates associations with brain-derived neurotrophic factor (BDNF) and catechol-O-methyltransferase (COMT). The purpose of this study was to quantify BDNF and COMT in plasma and in neuronal-enriched extracellular vesicles (nEVs), assess relationships with psychological symptoms, and gain insight on the brain-gut connection in IBS.

Methods

Clinical data and biorepository samples from a parent investigation were used, including scores on the Perceived Stress Scale (PSS) and Center for Epidemiological Studies Depression Scale (CES-D). Distinct subpopulations of nEVs were is

SUBMITTER: Weaver KR 

PROVIDER: S-EPMC9358931 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature