Long-term and serious harms of medical cannabis and cannabinoids for chronic pain: a systematic review of non-randomised studies.

ABSTRACT:

Objective

To establish the prevalence of long-term and serious harms of medical cannabis for chronic pain.

Design

Systematic review and meta-analysis.

Data sources

MEDLINE, EMBASE, PsycINFO and CENTRAL from inception to 1 April 2020.

Study selection

Non-randomised studies reporting on harms of medical cannabis or cannabinoids in adults or children living with chronic pain with ≥4 weeks of follow-up.

Data extraction and synthesis

A parallel guideline panel provided input on the design and interpretation of the systematic review, including selection of adverse events for consideration. Two reviewers, working independently and in duplicate, screened the search results, extracted data and assessed risk of bias. We used random-effects models for all meta-anal

SUBMITTER: Zeraatkar D 

PROVIDER: S-EPMC9358949 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature