Postradiation Optic Atrophy Is Associated With Intraocular Pressure and May Manifest With Neuroretinal Rim Thinning.

ABSTRACT:

Background

To determine risk factors for postradiation optic atrophy (PROA) after plaque radiotherapy for uveal melanoma.

Methods

A single center, retrospective cohort study of patients diagnosed with uveal melanoma involving choroid and/or ciliary body treated with plaque between January 1, 2008, and December 31, 2016. Outcomes included development of PROA with pallor alone or with concomitant neuroretinal rim thinning (NRT). Cox regression analysis was performed to identify risk factors for PROA.

Results

Of 78 plaque-irradiated patients, PROA developed in 41 (53%), with concomitant NRT in 15 (19%). Risk factors for PROA of any type included presentation with worse visual acuity (odds ratio [95% confidence interval] 5.6 [2.3-14.1], P < 0.001), higher baseline intraoc

SUBMITTER: Dalvin LA 

PROVIDER: S-EPMC9358970 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature