To explore association between gamma-glutamyl transferase and type 2 diabetes using a real-world study and mendelian randomization analysis.

ABSTRACT:

Aim

The association between gamma-glutamyl transferase (GGT) and type 2 diabetes mellitus (T2DM) is controversial. In this study, we investigated the association between GGT and the risk of T2DM using real-world data, Mendelian randomization (MR) analysis, and literature mining.

Methods

A cross-sectional study enrolled 3,048 participants (>40 years) from a community in Northeastern China was conducted. A generalized additive model was used to examine the relation between GGT and T2DM. A two-sample MR was performed to investigate the causal effect of GGT (61,089 individuals, mostly of European ancestry) on T2DM (29,193 cases and 182,573 controls of European ancestry).

Results

GGT was related to glucose metabolism indicators, such as fasting plasma glucose and glycosyla

SUBMITTER: Bi Y 

PROVIDER: S-EPMC9359111 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature