A distinct lipid metabolism signature of acute myeloid leukemia with prognostic value.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is a highly aggressive hematological malignancy characterized by extensive genetic abnormalities that might affect the prognosis and provide potential drug targets for treatment. Reprogramming of lipid metabolism plays important roles in tumorigenesis and progression and has been newly recognized a new hallmark of malignancy, and some related molecules in the signal pathways could be prognostic biomarkers and potential therapeutic targets for cancer treatment. However, the clinical value of lipid metabolism reprogramming in AML has not been systematically explored. In this study, we aim to explore the clinical value of lipid metabolism reprogramming and develop a prognostic risk signature for AML.

Methods

We implemented univariate Cox

SUBMITTER: Li D 

PROVIDER: S-EPMC9359125 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature