A modified mouse model for observational fear learning and the influence of social hierarchy.

ABSTRACT:

Background

Indirectly experiencing traumatic events either by witnessing or learning of a loved one's suffering is associated with the highest prevalence rates of epidemiological features of PTSD. Social species can develop fear by observing conspecifics in distress. Observational fear learning (OFL) is one of the most widely used paradigms for studying fear contagion in mice. However, the impact of empathic fear behavior and social hierarchy on fear transfer in mice is not well understood.

Methods

Fear emotions are best characterized in mice by using complementary tests, rather than only freezing behavior, and simultaneously avoiding behavioral variability in different tests across time. In this study, we modified the OFL model by implementing freezing (FZ), open field (OF)

SUBMITTER: Shi T 

PROVIDER: S-EPMC9359141 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature