Genome-Wide Association Study of Incident Dementia in a Community-Based Sample of Older Subjects.

ABSTRACT:

Background

Alzheimer's disease (AD) is a complex disease influenced by the environment and genetics; however, much of the genetic component remains unaccounted for.

Objective

The purpose of this work was to use genome-wide association analyses to detect genetic associations with incident AD in a sample of older adults aged 75 and above.

Methods

We performed a genome-wide association study (GWAS) on genome-wide genotyped and imputed data (14,072,053 variants) on the Gingko Evaluation of Memory (GEM) study sample consisting of 424 incident dementia (mean age = 84.46±3.91) and 2,206 non-demented (mean age = 84.55±3.23) subjects.

Results

The established association of APOE*4 carriers with AD was confirmed in this community-based sample of older subjects (odds ratio

SUBMITTER: Harper JD 

PROVIDER: S-EPMC9359180 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature