Development of a Highly Sensitive Neurofilament Light Chain Assay on an Automated Immunoassay Platform.

ABSTRACT:

Background

Neurofilament light chain (NfL) is an axonal cytoskeletal protein that is released into the extracellular space following neuronal or axonal injury associated with neurological conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), and other diseases. NfL is detectable in the cerebrospinal fluid (CSF) and blood. Numerous studies on MS have demonstrated that NfL is correlated with disease activity, predicts disease progression, and is reduced by treatment with MS disease-modifying drugs, making NfL an attractive candidate to supplement existing clinical and imaging measures in MS. However, for NfL to achieve its potential as a clinically useful biomarker for clinical decision-making or drug development, a standardized, practical, and widely acces

SUBMITTER: Lee S 

PROVIDER: S-EPMC9359312 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature