The Zonulin-transgenic mouse displays behavioral alterations ameliorated via depletion of the gut microbiota.

ABSTRACT: The gut-brain axis hypothesis suggests that interactions in the intestinal milieu are critically involved in regulating brain function. Several studies point to a gut-microbiota-brain connection linking an impaired intestinal barrier and altered gut microbiota composition to neurological disorders involving neuroinflammation. Increased gut permeability allows luminal antigens to cross the gut epithelium, and via the blood stream and an impaired blood-brain barrier (BBB) enters the brain impacting its function. Pre-haptoglobin 2 (pHP2), the precursor protein to mature HP2, is the first characterized member of the zonulin family of structurally related proteins. pHP 2 has been identified in humans as the thus far only endogenous regulator of epithelial and endothelial tight junctions (TJs).

SUBMITTER: Miranda-Ribera A 

PROVIDER: S-EPMC9359372 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature