LINC00173 promotes Wilms' tumor progression through MGAT1-mediated MUC3A N-glycosylation.

ABSTRACT: Recent studies have unveiled that LINC00173 promotes small cell lung cancer progression. However, LINC00173 has not been studied in Wilms' tumor (WT). N-glycosylation is a complex post-translational protein modification, and alterations of protein glycosylation have been identified to affect the development of multiple tumors, including WT. MGAT1, known as N-acetylglucosaminyltransferase I (GlcNAcT-1), could initiate synthesis of complex N-glycans, but it has never been related to LINC00173 in WT. This study aimed to explore if LINC00173 could impact WT progression via MGAT1. RT-qPCR and western blot were done to measure the expression and protein levels. Functional assays, as well as animal experiments were conducted to evaluate the function of genes in vivo an

SUBMITTER: Zhu Q 

PROVIDER: S-EPMC9359378 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature