Understanding Pathogenesis Intersects With Effective Treatment for Thyroid Eye Disease.

ABSTRACT:

Context

Thyroid eye disease (TED), a vision-threatening and disfiguring autoimmune process, has thwarted our efforts to understand its pathogenesis and develop effective and safe treatments. Recent scientific advances have facilitated improved treatment options.

Objective

Review historically remote and recent advances in understanding TED.

Design/setting/participants

PubMed was scanned using search terms including thyroid-associated ophthalmopathy, thyroid eye disease, Graves' orbitopathy, autoimmune thyroid disease, and orbital inflammation.

Main outcome measures

Strength of scientific evidence, size, scope, and controls of clinical trials/observations.

Results

Glucocorticoid steroids are widely prescribed systemic medical therapy. They can lessen infla

SUBMITTER: Smith TJ 

PROVIDER: S-EPMC9359447 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature