Estimation of Breast Cancer Overdiagnosis in a U.S. Breast Screening Cohort.

ABSTRACT:

Background

Mammography screening can lead to overdiagnosis-that is, screen-detected breast cancer that would not have caused symptoms or signs in the remaining lifetime. There is no consensus about the frequency of breast cancer overdiagnosis.

Objective

To estimate the rate of breast cancer overdiagnosis in contemporary mammography practice accounting for the detection of nonprogressive cancer.

Design

Bayesian inference of the natural history of breast cancer using individual screening and diagnosis records, allowing for nonprogressive preclinical cancer. Combination of fitted natural history model with life-table data to predict the rate of overdiagnosis among screen-detected cancer under biennial screening.

Setting

Breast Cancer Surveillance Consortium (BCSC)

SUBMITTER: Ryser MD 

PROVIDER: S-EPMC9359467 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature