Ontology highlight
ABSTRACT:
SUBMITTER: Wisniewski S
PROVIDER: S-EPMC9359563 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Wisniewski Szymon S Dragan Paulina P Makal Anna A Latek Dorota D
PLoS computational biology 20220721 7
Host response to infection involves the activation of the complement system leading to the production of anaphylatoxins C3a and C5a. Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and triggers the G protein-coupled signaling cascade. Orthosteric and allosteric antagonists of C5aR1 are a novel strategy for anti-inflammatory therapies. Here, we discuss recent crystal structures of inactive C5aR1 in terms of an inverted orientation of helix H8, unob ...[more]