Structural basis for inhibition and regulation of a chitin synthase from Candida albicans.
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ABSTRACT:
SUBMITTER: Ren Z
PROVIDER: S-EPMC9359617 | biostudies-literature | 2022 Jul
REPOSITORIES: biostudies-literature
Publications
Structural basis for inhibition and regulation of a chitin synthase from Candida albicans.
Ren Zhenning Z Chhetri Abhishek A Guan Ziqiang Z Suo Yang Y Yokoyama Kenichi K Lee Seok-Yong SY
Nature structural & molecular biology 20220704 7
Chitin is an essential component of the fungal cell wall. Chitin synthases (Chss) catalyze chitin formation and translocation across the membrane and are targets of antifungal agents, including nikkomycin Z and polyoxin D. Lack of structural insights into the action of these inhibitors on Chs has hampered their further development to the clinic. We present the cryo-EM structures of Chs2 from Candida albicans (CaChs2) in the apo, substrate-bound, nikkomycin Z-bound, and polyoxin D-bound states. C ...[more]
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