The European and Japanese eel NaCl cotransporters β exhibit chloride currents and are resistant to thiazide type diuretics.

ABSTRACT: The thiazide-sensitive Na⁺-Cl^- cotransporter (NCC) is the major pathway for salt reabsorption in the mammalian distal convoluted tubule, and the inhibition of its function with thiazides is widely used for the treatment of arterial hypertension. In mammals and teleosts, NCC is present as one ortholog that is mainly expressed in the kidney. One exception, however, is the eel, which has two genes encoding NCC. The eNCCα is located in the kidney and eNCCβ, which is present in the apical membrane of the rectum. Interestingly, the European eNCCβ functions as a Na⁺-Cl^- cotransporter that is nevertheless resistant to thiazides and is not activated by low-chloride hypotonic stress. However, in the Japanese eel rectal sac, a thiazide-sensitive NaCl transp

SUBMITTER: Moreno E 

PROVIDER: S-EPMC9359660 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature