Type 1 piliated uropathogenic <i>Escherichia coli</i> hijack the host immune response by binding to CD14.

ABSTRACT: A key attribute of persistent or recurring bacterial infections is the ability of the pathogen to evade the host's immune response. Many Enterobacteriaceae express type 1 pili, a pre-adapted virulence trait, to invade host epithelial cells and establish persistent infections. However, the molecular mechanisms and strategies by which bacteria actively circumvent the immune response of the host remain poorly understood. Here, we identified CD14, the major co-receptor for lipopolysaccharide detection, on mouse dendritic cells (DCs) as a binding partner of FimH, the protein located at the tip of the type 1 pilus of Escherichia coli. The FimH amino acids involved in CD14 binding are highly conserved across pathogenic and non-pathogenic strains. Binding of the pathogenic strain CFT

SUBMITTER: Tomasek K 

PROVIDER: S-EPMC9359703 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature