Somatic and Germline Genomic Alterations in Very Young Women with Breast Cancer.

ABSTRACT:

Purpose

Young age at breast cancer diagnosis correlates with unfavorable clinicopathologic features and worse outcomes compared with older women. Understanding biological differences between breast tumors in young versus older women may lead to better therapeutic approaches for younger patients.

Experimental design

We identified 100 patients ≤35 years old at nonmetastatic breast cancer diagnosis who participated in the prospective Young Women's Breast Cancer Study cohort. Tumors were assigned a surrogate intrinsic subtype based on receptor status and grade. Whole-exome sequencing of tumor and germline samples was performed. Genomic alterations were compared with older women (≥45 years old) in The Cancer Genome Atlas, according to intrinsic subtype.

Results

Ninety-thre

SUBMITTER: Waks AG 

PROVIDER: S-EPMC9359721 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature