Systematic Evaluation of the Immune Environment of Small Intestinal Neuroendocrine Tumors.

ABSTRACT:

Purpose

The immune tumor microenvironment and the potential therapeutic opportunities for immunotherapy in small intestinal neuroendocrine tumors (siNET) have not been fully defined.

Experimental design

Herein, we studied 40 patients with primary and synchronous metastatic siNETs, and matched blood and normal tissue obtained during surgery. We interrogated the immune checkpoint landscape using multi-parametric flow cytometry. In addition, matched FFPE tissue was obtained for multi-parametric IHC to determine the relative abundance and distribution of T-cell infiltrate. Tumor mutational burden (TMB) was also assessed and correlated with immune infiltration.

Results

Effector tumor-infiltrating lymphocytes (TIL) had a higher expression of PD-1 in the tumor microenvironme

SUBMITTER: Vesely C 

PROVIDER: S-EPMC9359734 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature