The interaction between smoking and bladder cancer genetic variants on urothelial cancer risk by disease aggressiveness.

ABSTRACT:

Background

Smoking has shown interactions with bladder cancer (BC) genetic variants, especially N-acetyltransferase-2 (NAT2), a tobacco smoke metabolism gene, on BC risk. The interactions by disease aggressiveness are unknown.

Methods

We investigated the interaction between smoking and 18 single nucleotide polymorphisms (SNPs) for BC, individually and in a genetic risk score (GRS), on urothelial cancer (UC) risk including BC. We analysed data from 25,453 individuals with 520 incident UCs during follow-up, 339 non-aggressive (non-fatal, non-muscle invasive) and 163 aggressive (all other) UCs. Hazard ratios (HRs), absolute risks and additive and multiplicative interactions for two-by-two combinations of never/ever smoking with low/high genetic risk were calculated.

Results<

SUBMITTER: Teleka S 

PROVIDER: S-EPMC9359879 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature