Prognosis and recurrence patterns in patients with early stage lung cancer: a multi-state model approach.

ABSTRACT:

Background

We aimed to assess whether recurrence patterns affect survival and to use a multi-state model to predict the prognosis of early stage non-small cell lung cancer in patients who underwent surgical resection.

Methods

Patients with early stage non-small cell lung cancer who underwent surgical resection at two tertiary medical centers between 2010 and 2015 were retrospectively analyzed. A multi-state model was employed with one initial state (surgery), two intermediate states (locoregional recurrence, distant metastasis), and one absorbing state (death), comprising five transitions: surgery to locoregional recurrence, surgery to distant metastasis, surgery to death without recurrence, locoregional recurrence to death, and distant metastasis to death. Cox proportional

SUBMITTER: Jeong WG 

PROVIDER: S-EPMC9359942 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature