Comprehensive analysis of mutational profile and prognostic significance of complex glandular pattern in lung adenocarcinoma.

ABSTRACT:

Background

Complex glandular pattern (CGP) was included as high-grade pattern in the new grading system proposed by The International Association for the Study of Lung Cancer. We aimed to investigate the mutational profile and validate the prognostic significance and proper cut-off value to distinguish the aggressive behavior of CGP.

Methods

CGP was defined as nests of tumor cells with sieve-like perforation, fused glands with irregular borders or back-to-back glands without intervening stroma. Patients were categorized into four groups according to the percentage of CGP component (0%, 1-19%, 20-49%, 50-100%). Cox's proportional hazards model was applied to analyze recurrence free survival (RFS) and overall survival (OS).

Results

A total of 950 patients with resected

SUBMITTER: Bai J 

PROVIDER: S-EPMC9359943 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature