Identification and validation of a ferroptosis-related prognostic risk-scoring model and key genes in small cell lung cancer.

ABSTRACT:

Background

Small cell lung cancer (SCLC) is an aggressive lung malignancy with high relapse rates and poor survival outcomes. Ferroptosis is a recently identified type of cell death caused by excessive intracellular iron accumulation and lipid peroxidation, which may mediate tumor-infiltrating immune cells to influence anti-cancer immunity. But prognostic value of ferroptosis-related genes and its relationship with the treatment response of immunotherapies in SCLC have not been elucidated.

Methods

The RNA-sequencing and clinical data of SCLC patients were downloaded from the cBioPortal database. A ferroptosis-related prognostic risk-scoring model was constructed based on univariable and multivariable Cox-regression analysis. Kaplan-Meier (K-M) survival curves and receiver op

SUBMITTER: Li S 

PROVIDER: S-EPMC9359951 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature