ID1 marks the tumorigenesis of pancreatic ductal adenocarcinoma in mouse and human.

ABSTRACT: Pancreatic Ductal Adenocarcinoma (PDAC) is a deadly disease that has an increasing death rate but no effective treatment to now. Although biological and immunological hallmarks of PDAC have been frequently reported recently, early detection and the particularly aggressive biological features are the major challenges remaining unclear. In the current study, we retrieved multiple scRNA-seq datasets and illustrated the genetic programs of PDAC development in genetically modified mouse models. Notably, the transcription levels of Id1 were elevated specifically along with the PDAC development. Pseudotime trajectory analysis revealed that Id1 was closely correlated with the malignancy of PDAC. The gene expression patterns of human PDAC cells were determined by the comparative analysis of the scR

SUBMITTER: Tang Y 

PROVIDER: S-EPMC9359991 | biostudies-literature | 2022 Aug

REPOSITORIES: biostudies-literature