Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial.

ABSTRACT:

Background

Psychostimulants are frequently used to treat attention-deficit/hyperactivity disorder (ADHD), but side effects are common leading to many patients discontinuing treatment. Identifying neural mechanisms by which psychostimulants attenuate symptoms may guide the development of more refined and tolerable therapeutics.

Methods

We conducted a 12-week, randomized, placebo-controlled trial (RCT) of a long-acting amphetamine, lisdexamfetamine (LDEX), in patients with ADHD, ages 6-25 years old. Of the 58 participants who participated in the RCT, 49 completed pre- and post-RCT magnetic resonance imaging scanning with adequate data quality. Healthy controls (HCs; n = 46) were included for comparison. Treatment effects on striatal and thalamic functional connectivity (FC) we

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9360200 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature