Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay.

ABSTRACT:

Background

The haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis. As thrombin is the central enzyme in the coagulation pathway, it is desirable to measure thrombin generation (TG) in order to detect possible bleeding or thrombotic phenotypes, as well as to investigate the capacity of drugs affecting the formation of thrombin. By investigating the underlying processes of TG (i.e., prothrombin conversion and inactivation), additional information is collected about the dynamics of thrombin formation.

Objectives

To obtain reference values for thrombin dynamics (TD) analysis in 112 healthy donors using an automated system for TG.

Methods

TG was measured on the ST Genesia, fibrinogen on the S

SUBMITTER: Carlo A 

PROVIDER: S-EPMC9360406 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature