Identification of gut metabolites associated with Parkinson's disease using bioinformatic analyses.

ABSTRACT:

Background

Parkinson's disease (PD) is a common neurodegenerative disease affecting the movement of elderly patients. Environmental exposures are the risk factors for PD; however, gut environmental risk factors for PD are critically understudied. The proof-of-concept study is to identify gut metabolites in feces, as environmental exposure risk factors, that are associated with PD and potentially increase the risk for PD by using leverage of known toxicology results.

Materials and methods

We collected the data regarding the gut metabolites whose levels were significantly changed in the feces of patients with PD from the original clinical studies after searching the following databases: EBM Reviews, PubMed, Embase, MEDLINE, and Elsevier ClinicalKey. We further searched each ca

SUBMITTER: Yan J 

PROVIDER: S-EPMC9360421 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature